1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride

Base Information

Chemical Name:1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride
CAS No.:1620955-80-7
Molecular Formula:C₂₆H₂₃N₅O₃*ClH
Molecular Weight:489.961
Hs Code.:

Synonyms:1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride

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Chemical Property of 1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride

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Technology Process of 1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride

There total 9 articles about 1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620955-79-4
C₃₅H₃₉N₅O₅

: 1620955-80-7
1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 191338-94-0
ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate

: 1620955-80-7
1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / ethanol / 2 h / Reflux

1.2: 16 h

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C

3.1: caesium carbonate / ethanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

3.2: 8 h / Reflux

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1054478-77-1
2-(4-bromophenyl)-1,6-naphthyridine-4-carboxylic acid

: 1620955-80-7
1-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)pyrrolidine-3-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C

2.1: caesium carbonate / ethanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

2.2: 8 h / Reflux

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;