(1S,2S)-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1,2-dihydroxypropylphosphonic acid

Base Information

Chemical Name:(1S,2S)-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1,2-dihydroxypropylphosphonic acid
CAS No.:1616268-22-4
Molecular Formula:C₁₇H₁₈N₅O₈P
Molecular Weight:451.332
Hs Code.:

Synonyms:(1S,2S)-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1,2-dihydroxypropylphosphonic acid

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Chemical Property of (1S,2S)-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1,2-dihydroxypropylphosphonic acid

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Technology Process of (1S,2S)-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1,2-dihydroxypropylphosphonic acid

There total 2 articles about (1S,2S)-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1,2-dihydroxypropylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1616268-19-9
(1S,2S)-dibenzyl 2-benzyloxy-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1-hydroxypropylphosphonate

: 1616268-22-4
(1S,2S)-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1,2-dihydroxypropylphosphonic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2014.05.020

Reference yield:

: 449152-75-4
N³-benzoyl-N¹-propargyluracil

: 1616268-22-4
(1S,2S)-3-{4-[(3-benzoyl-2,4-dioxopyrimidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}-1,2-dihydroxypropylphosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / ethanol; water / 0.33 h / 40 - 45 °C / Microwave irradiation

2: hydrogen; palladium 10% on activated carbon / methanol; water / 48 h / 20 °C

With copper(ll) sulfate pentahydrate; palladium 10% on activated carbon; hydrogen; sodium L-ascorbate; In methanol; ethanol; water;
DOI:10.1016/j.bmc.2014.05.020