4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol

Base Information

Chemical Name:4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol
CAS No.:1443151-99-2
Molecular Formula:C₂₀H₂₀ClFN₄O₂
Molecular Weight:402.856
Hs Code.:

Synonyms:4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol

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Chemical Property of 4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol

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Technology Process of 4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol

There total 3 articles about 4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443151-51-6
C₂₁H₂₂ClFN₄O₂

: 1443151-99-2
4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol

Guidance literature:: With methanol; sodium methylate; for 5h; Reflux;

Reference yield:

: 1283063-82-0
4-chloro-N-[2-(4-fluorophenyl)ethyl]-6-methoxy-1,3,5-triazin-2-amine

: 1443151-99-2
4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / Reflux

2: sodium methylate / methanol / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate; caesium carbonate; In methanol; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.11.023

Reference yield:

: 1583-88-6
4-fluoro-2-phenethylamine

: 1443151-99-2
4-[4-chloro-3-(1-hydroxy-1-methylethyl)phenyl]-6-{[2-(4-fluorophenyl)ethyl]amino}-1,3,5-triazin-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0 °C

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / Reflux

3: sodium methylate / methanol / Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.11.023