Codeine phosphate hydrate

Base Information

• Chemical Name: Codeine phosphate hydrate
• CAS No.: 52-28-8
• Molecular Formula: C18H21NO3•H3O4P
• Molecular Weight: 397.365
• European Community (EC) Number: 200-137-8
• NCI Thesaurus Code: C74548
• RXCUI: 2672,1652891
• ChEMBL ID: CHEMBL1201099
• Mol file: 52-28-8.mol

Synonyms:Ardinex;Codeine;Codeine Phosphate;Isocodeine;Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-;N Methylmorphine;N-Methylmorphine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Codeine phosphate hydrate

Chemical Property:

• Appearance/Colour: White to off-white solid
• Melting Point: 238-240 °C
• Boiling Point: 462 °C at 760 mmHg
• Flash Point: 233.2 °C
• PSA: 98.27000
• LogP: 1.55600
• Storage Temp.: Controlled Substance, -20°C Freezer
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 1
• Exact Mass: 415.13960379
• Heavy Atom Count: 28
• Complexity: 558

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O.O.OP(=O)(O)O
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O.O.OP(=O)(O)O
• Recent ClinicalTrials: Colonic Motor Patterns in Healthy Volunteers
• Recent EU Clinical Trials: THE RELATIONSHIP BETWEEN GASTRIC MOTILITY AND EMPTYING AS MEASURED WITH AN INTRAGASTRIC BALLOON AND BREATH TESTING
• Uses: Present in opium from 0.7% to 2.5%, depending on the source. Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antitussive. Controlled substance (opiate)

Technology Process of Codeine phosphate hydrate

There total 5 articles about Codeine phosphate hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenyltrimethylammonium chloride (138-24-9) + MORPHIN (57-27-2) → codeine phosphate (52-28-8)

Guidance literature:

phenyltrimethylammonium chloride; MORPHIN; With potassium phosphate; In acetone; at 50 - 60 ℃; for 25h; Heating / reflux;

With phosphoric acid; In water; acetone; at 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 100.0%

morphine (57-27-2,143-70-4,6912-73-8,16206-77-2,27067-73-8,65165-99-3,70982-47-7) → codeine phosphate (52-28-8,4478-25-5,17682-64-3,56050-09-0,76034-17-8)

Guidance literature:

morphine; With potassium dihydrogenphosphate; phenyltrimethylammonium chloride; In acetone; at 50 - 60 ℃; for 25h;

In acetone; activated charcoal;

With phosphoric acid; In acetone; at 20 ℃; for 0.5h;

Reference yield: 99.8%

morphine (57-27-2,143-70-4,6912-73-8,16206-77-2,27067-73-8,65165-99-3,70982-47-7) + phenyltrimethylammonium chloride (138-24-9) → codeine phosphate (52-28-8,4478-25-5,17682-64-3,56050-09-0,76034-17-8)

Guidance literature:

morphine; phenyltrimethylammonium chloride; With potassium hydrogencarbonate; In toluene; at 50 - 115 ℃; for 29h; Heating / reflux;

In toluene; at 20 ℃; activated carbon (charcoal);

With phosphoric acid; In ethanol; water; at 20 ℃; for 0.5h;

upstream raw materials:

phenyltrimethylammonium chloride

MORPHIN

codeine

morphine

Downstream raw materials:

10-Hydroxycodein

6β-chloro-4,5α-epoxy-3-methoxy-17-methyl-morphin-7-ene

pseudocodeine

codeine

Refernces

• 1、 -. "PROCESS FOR THE PRODUCTION OF OPIATES". Page/Page column 4-5. . Retrieved 2008/06/13.