5-methoxy-N-propyl-2,3,4,4a,9,9a-hexahydro-1-H-indeno(2,1-c)pyridine

Base Information

Chemical Name:5-methoxy-N-propyl-2,3,4,4a,9,9a-hexahydro-1-H-indeno(2,1-c)pyridine
CAS No.:135064-20-9
Molecular Formula:C₁₆H₂₃NO
Molecular Weight:245.365
Hs Code.:
Mol file:135064-20-9.mol

Synonyms:1H-Indeno[2,1-c]pyridine,2,3,4,4a,9,9a-hexahydro-5-methoxy-2-propyl-, cis-

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Chemical Property of 5-methoxy-N-propyl-2,3,4,4a,9,9a-hexahydro-1-H-indeno(2,1-c)pyridine

Chemical Property:

Vapor Pressure:6.65E-05mmHg at 25°C
Boiling Point:344.3°Cat760mmHg
Flash Point:101.7°C
Density:1.023g/cm³

Purity/Quality:

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Technology Process of 5-methoxy-N-propyl-2,3,4,4a,9,9a-hexahydro-1-H-indeno(2,1-c)pyridine

There total 24 articles about 5-methoxy-N-propyl-2,3,4,4a,9,9a-hexahydro-1-H-indeno(2,1-c)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10516-71-9
3-(3-Methoxy-phenyl)-propionic acid

: 135064-20-9
cis-5-methoxy-2-propyl-2,3,4,4a,9,9a-hexahydro-1H-indeno<2,1-c>pyridine

Guidance literature:: Multi-step reaction with 11 steps

1: 91 percent / bromine / CH₂Cl₂ / 0.25 h / 0 °C

2: 66 percent / polyphosphoric acid / 1 h / 60 °C

3: 1.) BF₃*Et₂O, 2.) ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, -78 to -15 deg C, 2 h

4: 1.) LiHMDS / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2.5 h

5: 91 percent / NaOAc*3H₂O, H₂ / 10 percent Pd/C / ethanol / 3040 Torr

6: 6.0 M aq. HCl / tetrahydrofuran / 2.5 h / 25 °C

7: aq. AgNO₃, aq. KOH / ethanol / 0.5 h

8: 96 percent H₂SO₄ / 2 h / Heating

9: 1.) trimethylaluminium / 1.) toluene, 1 h, 2.) toluene, reflux, 2.5 h

10: p-TsOH / xylene / 48 h / Heating

11: BH₃*THF / tetrahydrofuran / 4 h / Heating

With hydrogenchloride; potassium hydroxide; PPA; borane-THF; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; bromine; trimethylaluminum; sodium acetate; toluene-4-sulfonic acid; silver nitrate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; xylene;

Reference yield:

: 10516-71-9
3-(3-Methoxy-phenyl)-propionic acid

: 135064-20-9
trans-5-methoxy-2-propyl-2,3,4,4a,9,9a-hexahydro-1H-indeno<2,1-c>pyridine

Guidance literature:: Multi-step reaction with 11 steps

1: 91 percent / bromine / CH₂Cl₂ / 0.25 h / 0 °C

2: 66 percent / polyphosphoric acid / 1 h / 60 °C

3: 1.) BF₃*Et₂O, 2.) ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, -78 to -15 deg C, 2 h

4: 1.) LiHMDS / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2.5 h

5: 91 percent / NaOAc*3H₂O, H₂ / 10 percent Pd/C / ethanol / 3040 Torr

6: 6.0 M aq. HCl / tetrahydrofuran / 2.5 h / 25 °C

7: aq. AgNO₃, aq. KOH / ethanol / 0.5 h

8: 96 percent H₂SO₄ / 2 h / Heating

9: 1.) trimethylaluminium / 1.) toluene, 1 h, 2.) toluene, reflux, 2.5 h

10: p-TsOH / xylene / 48 h / Heating

11: BH₃*THF / tetrahydrofuran / 4 h / Heating

With hydrogenchloride; potassium hydroxide; PPA; borane-THF; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; bromine; trimethylaluminum; sodium acetate; toluene-4-sulfonic acid; silver nitrate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; xylene;

Reference yield:

: 66192-02-7
3-(2-bromo-5-methoxyphenyl)propanoic acid

: 135064-20-9
cis-5-methoxy-2-propyl-2,3,4,4a,9,9a-hexahydro-1H-indeno<2,1-c>pyridine

Guidance literature:: Multi-step reaction with 10 steps

1: 66 percent / polyphosphoric acid / 1 h / 60 °C

2: 1.) BF₃*Et₂O, 2.) ethyldiisopropylamine / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, -78 to -15 deg C, 2 h

3: 1.) LiHMDS / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2.5 h

4: 91 percent / NaOAc*3H₂O, H₂ / 10 percent Pd/C / ethanol / 3040 Torr

5: 6.0 M aq. HCl / tetrahydrofuran / 2.5 h / 25 °C

6: aq. AgNO₃, aq. KOH / ethanol / 0.5 h

7: 96 percent H₂SO₄ / 2 h / Heating

8: 1.) trimethylaluminium / 1.) toluene, 1 h, 2.) toluene, reflux, 2.5 h

9: p-TsOH / xylene / 48 h / Heating

10: BH₃*THF / tetrahydrofuran / 4 h / Heating

With hydrogenchloride; potassium hydroxide; PPA; borane-THF; sulfuric acid; boron trifluoride diethyl etherate; hydrogen; trimethylaluminum; sodium acetate; toluene-4-sulfonic acid; silver nitrate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; xylene;