(±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone

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Chemical Name:(±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone
CAS No.:1614264-73-1
Molecular Formula:C₁₆H₁₅BrN₂O₃
Molecular Weight:363.211
Hs Code.:

Synonyms:(±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone

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Chemical Property of (±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone

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Technology Process of (±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone

There total 1 articles about (±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 2033-24-1
cycl-isopropylidene malonate

: 2-cyanoethyl 2-oxobutanoate

: 1122-91-4
4-bromo-benzaldehyde

: 1614264-73-1
(±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone

Guidance literature:: With ammonium acetate; acetic acid; at 110 ℃; for 14h; Reflux;
DOI:10.1016/j.tet.2014.05.012

Reference yield: 94.0%

: 1614264-73-1
(±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone

: 1614264-77-5
(±)-4-(4-bromophenyl)-5-carboxy-6-methyl-3,4-dihydro-2(1H)-pyridone

Guidance literature:: With water; sodium hydroxide; In acetone; at 20 ℃;
DOI:10.1016/j.tet.2014.05.012

Reference yield:

: 1614264-73-1
(±)-4-(4-bromophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone

: 1334529-05-3
methyl 4-(4-bromophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / acetone / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide

2.2: 24 h / 20 °C

3.1: water; Candida antarctica lipase B / tert-butyl methyl ether / 11 h / 28 °C / Enzymatic reaction

4.1: water; Candida antarctica lipase B / tert-butyl methyl ether / 2.5 h / 28 °C / Enzymatic reaction

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h

5.2: 4 h / 20 °C

With Candida antarctica lipase B; water; caesium carbonate; sodium hydroxide; In tert-butyl methyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2014.05.012