(2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane

Base Information

Chemical Name:(2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane
CAS No.:885065-64-5
Molecular Formula:C₂₈H₃₈O₄Si
Molecular Weight:466.693
Hs Code.:

Synonyms:(2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane

Suppliers and Price of (2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane

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Technology Process of (2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane

There total 5 articles about (2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 885065-70-3
Toluene-4-sulfonic acid (2S,4R)-4-(tert-butyl-diphenyl-silanyloxy)-4-(R)-1,4-dioxa-spiro[4.5]dec-2-yl-2-hydroxy-butyl ester

: 885065-64-5
(2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane

Guidance literature:: With potassium carbonate; In methanol; at 0 ℃; for 3h;
DOI:10.1016/j.tetasy.2006.01.027

Reference yield:

: 885065-62-3
(4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxyhex-1-ene

: 885065-64-5
(2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / AD mix-β / 2-methyl-propan-2-ol; H2O / 18 h / 0 °C

2: 94 percent / pyridine / CH₂Cl₂ / 12 h / 0 °C

3: 86 percent / K₂CO₃ / methanol / 3 h / 0 °C

With pyridine; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.tetasy.2006.01.027

Reference yield:

: 885065-63-4
(2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxyhexane-1,2-diol

: 885065-64-5
(2S,4R,5R)-4-tert-butyldiphenylsilyloxy-5,6-cyclohexylidenedioxy-1,2-epoxyhexane

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine / CH₂Cl₂ / 12 h / 0 °C

2: 86 percent / K₂CO₃ / methanol / 3 h / 0 °C

With pyridine; potassium carbonate; In methanol; dichloromethane;
DOI:10.1016/j.tetasy.2006.01.027