tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate

Base Information

Chemical Name:tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate
CAS No.:1310493-54-9
Molecular Formula:C₁₉H₃₀N₂O₄S
Molecular Weight:382.524
Hs Code.:

Synonyms:tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate

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Chemical Property of tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate

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Technology Process of tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate

There total 6 articles about tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1306598-67-3
tert-butyl [(1S,2S)-2-aminocyclohexyl]methylcarbamate

: 98-59-9
p-toluenesulfonyl chloride

: 1310493-54-9
tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate

Guidance literature:: With triethylamine; In chloroform; for 5h; Reflux;
DOI:10.1021/jo200834n

Reference yield:

: 1310493-53-8
tert-butyl [(1S,2S)-2-(benzylamino)cyclohexyl]methylcarbamate

: 1310493-54-9
tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 760.05 Torr / Reflux

2: triethylamine / chloroform / 5 h / Reflux

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; chloroform;
DOI:10.1021/jo200834n

Reference yield:

: 1310493-51-6
N-[(1S,2R)-2-carbamoylcyclohexyl]benzamide

: 1310493-54-9
tert-butyl [(1S,2S)-2-(4-methylphenylsulfonamido)cyclohexyl]methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 96 h / 0 °C / Reflux; Inert atmosphere

2: thiourea / toluene / 0.5 h / 70 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 760.05 Torr / Reflux

4: triethylamine / chloroform / 5 h / Reflux

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; triethylamine; thiourea; In tetrahydrofuran; methanol; chloroform; toluene;
DOI:10.1021/jo200834n