N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.0^2,6.0^3,10.0^5,9.0^8,11]dodecan-3-ol

Base Information

• Chemical Name: N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.0^2,6.0^3,10.0^5,9.0^8,11]dodecan-3-ol
• CAS No.: 1314110-88-7
• Molecular Formula: C₂₁H₂₂FNO₂
• Molecular Weight: 339.41
• Mol file: 1314110-88-7.mol

Synonyms:N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.0^2,6.0^3,10.0^5,9.0^8,11]dodecan-3-ol

Chemical Property of N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.0^2,6.0^3,10.0^5,9.0^8,11]dodecan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.0^2,6.0^3,10.0^5,9.0^8,11]dodecan-3-ol

There total 6 articles about N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.0^2,6.0^3,10.0^5,9.0^8,11]dodecan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H30FNO4 → N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol (1314110-88-7)

Guidance literature:

C₂₅H₃₀FNO₄; With hydrogenchloride; In water; acetone; at 20 ℃; for 12h; Inert atmosphere;

With sodium hydroxide; In water; acetone; pH=14; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.04.098

Reference yield:

4-amino-1-(4-fluorophenyl)-1-butanone ethylene ketal (3308-93-8) → N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol (1314110-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 18 h / 100 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 8 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / water; acetone / 12 h / 20 °C / Inert atmosphere

3.2: pH 14 / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; In ethanol; water; acetone;

DOI:10.1016/j.bmcl.2011.04.098

Reference yield:

4-(4-fluorophenyl)-4-oxo-n-butyl chloride (3874-54-2,41167-07-1) → N-(4-(4-fluoro)butyrophenone)-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol (1314110-88-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / water; toluene / 16 h / Inert atmosphere; Reflux

2.1: sodium azide; potassium iodide / N,N-dimethyl-formamide / 26 h / 60 °C / Inert atmosphere

3.1: triphenylphosphine / diethyl ether / 0 - 20 °C / Inert atmosphere

3.2: 19 h / Inert atmosphere

4.1: ethanol / 18 h / 100 °C / Inert atmosphere

5.1: sodium tetrahydroborate / ethanol / 8 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / water; acetone / 12 h / 20 °C / Inert atmosphere

6.2: pH 14 / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; sodium azide; toluene-4-sulfonic acid; triphenylphosphine; potassium iodide; In diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone; toluene; 3.1: Staudinger reaction / 3.2: Staudinger reaction;

DOI:10.1016/j.bmcl.2011.04.098

upstream raw materials:

4-amino-1-(4-fluorophenyl)-1-butanone ethylene ketal

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

2-(3-azidopropyl)-2-(4-fluorophenyl)[1,3]dioxolane

4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane