7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

• Chemical Name: 7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
• CAS No.: 88156-75-6
• Molecular Formula: C₁₈H₂₀N₂O₄
• Molecular Weight: 328.368

Synonyms:7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property of 7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 3 articles about 7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

6-hydroxy-7-methoxy-N-methyl-N-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide (88156-74-5) → 7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (88156-75-6)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 35 ℃; for 50h;

DOI:10.1021/jo00178a001

Reference yield:

isocorypalline (13871-59-5) → 7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (88156-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / acetonitrile / Heating

2: 76 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 50 h / 35 °C

With potassium tert-butylate; In acetonitrile; tert-butyl alcohol;

DOI:10.1021/jo00178a001

Reference yield:

1-bromomethyl-4-nitro-benzene (100-11-8) → 7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (88156-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / acetonitrile / Heating

2: 76 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 50 h / 35 °C

With potassium tert-butylate; In acetonitrile; tert-butyl alcohol;

DOI:10.1021/jo00178a001

upstream raw materials:

6-hydroxy-7-methoxy-N-methyl-N-(p-nitrobenzyl)-1,2,3,4-tetrahydroisoquinolinium Bromide

isocorypalline

1-bromomethyl-4-nitro-benzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 88156-75-6 7-Hydroxy-8-methoxy-3-methyl-2-(p-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Send

Send

Metric Ton KG G Pound L ML

Send

Send