phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate

Base Information

Chemical Name:phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate
CAS No.:1269627-63-5
Molecular Formula:C₇H₉N*C₂₃H₂₈N₂O₄
Molecular Weight:503.641
Hs Code.:

Synonyms:phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate

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Chemical Property of phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate

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Technology Process of phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate

There total 7 articles about phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1269627-48-6
N-[(2E)-4-oxo-4-phenylbut-2-enoyl]-L-leucine

: 100-46-9
benzylamine

: 1269627-63-5
phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate

Guidance literature:: In water; at 40 ℃; for 120h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tetasy.2010.11.015

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 1269627-63-5
phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 1 h / 20 °C

2: water / 120 h / 40 °C

With sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; 2: Michael condensation;
DOI:10.1016/j.tetasy.2010.11.015

Reference yield:

: N-[(2R)-2-amino-4-(4-methoxyphenyl)butanoyl]-L-leucine

: 1269627-63-5
phenylmethanaminium (S)-2-((R)-2-(benzylamino)-4-oxo-4-phenylbutanamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / 30 h / Reflux

2: sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 1 h / 20 °C

3: water / 120 h / 40 °C

With hydrogenchloride; water; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; 3: Michael condensation;
DOI:10.1016/j.tetasy.2010.11.015