(3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide

Base Information

Chemical Name:(3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide
CAS No.:467457-08-5
Molecular Formula:C₂₈H₄₁N₃O₅S₂
Molecular Weight:563.783
Hs Code.:

Synonyms:(3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide

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Chemical Property of (3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide

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Technology Process of (3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide

There total 3 articles about (3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 98-59-9
p-toluenesulfonyl chloride

: 467457-07-4
(3R,7Z)-N-(4-aminobutyl)-3-{[(4-methylphenyl)sulfonyl]amino}dec-7-enamide

: 467457-08-5
(3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 1h;
DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E

Reference yield:

: 928-96-1
(Z)-3-Hexen-1-ol

: 467457-08-5
(3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / PPh₃; 1H-imidazole; I₂ / CH₂Cl₂ / 1 h / 20 °C

2: 0.85 g / CuBr*Me₂S; t-BuLi / tetrahydrofuran; diethyl ether / -78 - 20 °C

3: 100 percent / Cu(OAc)2 / 8 h / 20 °C

4: 93 percent / Et₃N / CHCl₃ / 1 h / 20 °C

With 1H-imidazole; copper(I) bromide dimethylsulfide complex; iodine; tert.-butyl lithium; triethylamine; triphenylphosphine; copper diacetate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform;
DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E

Reference yield:

: 467457-05-2
ethyl (+)-(3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}dec-7-enoate

: 467457-08-5
(3R,7Z)-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)dec-7-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Cu(OAc)2 / 8 h / 20 °C

2: 93 percent / Et₃N / CHCl₃ / 1 h / 20 °C

With triethylamine; copper diacetate; In chloroform;
DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E