3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide

Base Information

Chemical Name:3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide
CAS No.:1282520-35-7
Molecular Formula:C₂₅H₂₉N₃O₅
Molecular Weight:451.522
Hs Code.:

Synonyms:3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide

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Chemical Property of 3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide

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Technology Process of 3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide

There total 11 articles about 3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.2%

: 3-[2-(2,4-dimethoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide

: 1282520-35-7
3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 12h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282520-35-7
3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

5.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

6.1: thionyl chloride / 3 h / 100 °C

6.2: 12 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

8.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

9.1: 3 h / 160 °C

10.1: potassium tert-butylate / tetrahydrofuran / 12 h / 20 °C

11.1: hydrogen / palladium on activated charcoal / ethyl acetate / 12 h / 20 °C

With pyridine; methanol; thionyl chloride; borane-THF; di-isopropyl azodicarboxylate; tribromide phosphate; potassium tert-butylate; hydrogen; triphenylphosphine; potassium hydroxide; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 1282520-99-3
3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

: 1282520-35-7
3-[2-(2,4-dimethoxyphenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(pyrazin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

2.1: thionyl chloride / 3 h / 100 °C

2.2: 12 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

4.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

6.1: potassium tert-butylate / tetrahydrofuran / 12 h / 20 °C

7.1: hydrogen / palladium on activated charcoal / ethyl acetate / 12 h / 20 °C

With pyridine; thionyl chloride; tribromo phosphate; potassium tert-butylate; hydrogen; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;