N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-9-(2-((6-phenylmethoxycarbonylamino)-9H-purin-9-yl)acetyl)-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester

Base Information

• Chemical Name: N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-9-(2-((6-phenylmethoxycarbonylamino)-9H-purin-9-yl)acetyl)-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester
• CAS No.: 1352089-45-2
• Molecular Formula: C₆₁H₇₄N₁₈O₁₅
• Molecular Weight: 1299.37
• Mol file: 1352089-45-2.mol

Synonyms:N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-9-(2-((6-phenylmethoxycarbonylamino)-9H-purin-9-yl)acetyl)-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester

Chemical Property of N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-9-(2-((6-phenylmethoxycarbonylamino)-9H-purin-9-yl)acetyl)-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-9-(2-((6-phenylmethoxycarbonylamino)-9H-purin-9-yl)acetyl)-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester

There total 1 articles about N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-9-(2-((6-phenylmethoxycarbonylamino)-9H-purin-9-yl)acetyl)-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester (1352089-44-1) + [6-N-(benzyloxycarbonyl)-adenin-9-yl]-acetic acid (149376-67-0) → N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-9-(2-((6-phenylmethoxycarbonylamino)-9H-purin-9-yl)acetyl)-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester (1352089-45-2)

Guidance literature:

With bromo-tris-dimethylamino-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/hlca.201100243

Reference yield: 95.0%

N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-9-(2-((6-phenylmethoxycarbonylamino)-9H-purin-9-yl)acetyl)-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester (1352089-45-2) + trifluoroacetic acid (76-05-1) → Z-Aeg(H)-Aeg(A[z])-Aeg(G[z])-Aem*TFA

Guidance literature:

With triethylsilane; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1002/hlca.201100243

upstream raw materials:

N-(6,9-dihydro-9-(15-(tert-butoxycarbonyl)-3-(2-(2-(morpholin-4-yl)ethylamino)-2-oxoethyl)-2,7,13,19-tetraoxo-21-phenyl-20-oxa-3,6,9,12,15,18-hexaazaheneicos-1-yl)-6-oxo-1H-purin-2-yl)carbamic acid phenylmethyl ester

[6-N-(benzyloxycarbonyl)-adenin-9-yl]-acetic acid