3-O-MEM-nalbuphine

Base Information

• Chemical Name: 3-O-MEM-nalbuphine
• CAS No.: 1056881-05-0
• Molecular Formula: C₂₅H₃₅NO₆
• Molecular Weight: 445.556
• Mol file: 1056881-05-0.mol

Synonyms:3-O-MEM-nalbuphine

Chemical Property of 3-O-MEM-nalbuphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-MEM-nalbuphine

There total 1 articles about 3-O-MEM-nalbuphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxyethoxymethyl chloride (3970-21-6) + nalbuphine (20594-83-6) → 3-O-MEM-nalbuphine (1056881-05-0)

Guidance literature:

2-Methoxyethoxymethyl chloride; nalbuphine; With potassium carbonate; In acetone; toluene; at 20 ℃; for 21h;

With methanol; In acetone; toluene;

Reference yield:

TrO-PEG5-OMs (1056881-14-1) + 3-O-MEM-nalbuphine (1056881-05-0) → 3-O-MEM-6-O-TrO-PEG5-nalbuphine (1056881-16-3)

Guidance literature:

TrO-PEG₅-OMs; 3-O-MEM-nalbuphine; With sodium hydride; In N,N-dimethyl-formamide; toluene; at 20 - 60 ℃; for 20h;

With water; sodium chloride; In N,N-dimethyl-formamide; toluene; at 20 ℃;

Reference yield:

3-O-MEM-nalbuphine (1056881-05-0) + 2-(2-(2-<2-(triphenylmethoxy)ethoxy>ethoxy)ethoxy)ethyl methanesulfonate (146462-60-4) → 3-O-MEM-6-O-TrO-PEG4-nalbuphine (1056881-15-2)

Guidance literature:

3-O-MEM-nalbuphine; 2-(2-(2-<2-(triphenylmethoxy)ethoxy>ethoxy)ethoxy)ethyl methanesulfonate; With sodium hydride; In N,N-dimethyl-formamide; toluene; at 45 ℃; for 22.5h;

With water; sodium chloride; In N,N-dimethyl-formamide; toluene; at 20 ℃;

upstream raw materials:

2-Methoxyethoxymethyl chloride

nalbuphine

Downstream raw materials:

3-O-MEM-6-O-TrO-PEG₅-nalbuphine

3-O-MEM-6-O-TrO-PEG₄-nalbuphine