(E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one
CAS No.:1522361-81-4
Molecular Formula:C₁₅H₁₁ClO₅
Molecular Weight:306.702
Hs Code.:

Synonyms:(E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one

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Technology Process of (E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one

There total 5 articles about (E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1522361-73-4
(E)-1-(2,4-bis(allyloxy)-5-chlorophenyl)-3-(2,4-bis(allyloxy)phenyl)prop-2-en-1-one

: 1522361-81-4
(E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one

Guidance literature:: With trans-bis(triphenylphosphine)palladium dichloride; ammonium formate; In tetrahydrofuran; at 120 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.11.034

Reference yield:

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 1522361-81-4
(E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere

3: potassium hydroxide / methanol; water / 12 h / 20 °C / Inert atmosphere

4: trans-bis(triphenylphosphine)palladium dichloride; ammonium formate / tetrahydrofuran / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

With thionyl chloride; trans-bis(triphenylphosphine)palladium dichloride; ammonium formate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmcl.2013.11.034

Reference yield:

: 90110-32-0
1-(5-chloro-2,4-dihydroxyphenyl)ethan-1-one

: 1522361-81-4
(E)-1-(5-chloro-2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere

2: potassium hydroxide / methanol; water / 12 h / 20 °C / Inert atmosphere

3: trans-bis(triphenylphosphine)palladium dichloride; ammonium formate / tetrahydrofuran / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

With trans-bis(triphenylphosphine)palladium dichloride; ammonium formate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmcl.2013.11.034