tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate
CAS No.:1048963-82-1
Molecular Formula:C₂₀H₂₁ClF₂N₆O₂
Molecular Weight:450.876
Hs Code.:

Synonyms:tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate

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Chemical Property of tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate

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Technology Process of tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate

There total 4 articles about tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 916736-69-1
5-(2-bromo-4-chloro-6-fluorophenyl)-2-methyl-2H-tetrazole

: 1048963-82-1
tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate

Guidance literature:: tert-butyl [(1R)-1-(5-bromo-3-fluoropyridin-2-yl)ethyl]-carbamate; With potassium acetate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 90 ℃; for 16h;

5-(2-bromo-4-chloro-6-fluorophenyl)-2-methyl-2H-tetrazole; With potassium carbonate; In water; dimethyl sulfoxide; at 80 ℃; for 5h;

Reference yield:

: 916736-69-1
5-(2-bromo-4-chloro-6-fluorophenyl)-2-methyl-2H-tetrazole

: 1075221-18-9
C₁₈H₂₈BFN₂O₄

: 1048963-82-1
tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2008.07.126

Reference yield:

: 858414-22-9
2-bromo-4-chloro-6-fluorobenzonitrile

: 1048963-82-1
tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: azidotrimethyltin / toluene / 72 h / 120 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: potassium acetate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 90 °C

3.2: 5 h / 80 °C

With potassium acetate; azidotrimethyltin; potassium carbonate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;