(1s,3s)-3-phenylcyclobutanol

Base Information

• Chemical Name: (1s,3s)-3-phenylcyclobutanol
• CAS No.: 150639-15-9
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.205
• Mol file: 150639-15-9.mol

Synonyms:(1s,3s)-3-phenylcyclobutanol

Chemical Property of (1s,3s)-3-phenylcyclobutanol

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1s,3s)-3-phenylcyclobutanol

There total 12 articles about (1s,3s)-3-phenylcyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

borane N-isopropyl-N-(3-phenylcyclobutylidene)amine → (1s,3s)-3-phenylcyclobutanol (150639-15-9)

Guidance literature:

With sodium hydroxide; for 2h; Heating;

DOI:10.1016/j.tetlet.2006.03.023

Reference yield:

2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane (1716-70-7) → (1s,3s)-3-phenylcyclobutanol (150639-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / KOH / aq. ethanol / 21 h / Ambient temperature

2: 78 percent / conc. H₂SO₄ / 0.28 h / Heating

3: 96 percent / AcONa, H₂ / Pd/C / methanol

4: 80 percent / LiAlH₄ / diethyl ether

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium acetate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1021/ja00076a024

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → (1s,3s)-3-phenylcyclobutanol (150639-15-9)

Guidance literature:

Multi-step reaction with 5 steps

2: KOH / ethanol

3: H₂SO₄

4: H₂, NaOAc / Pd-C / methanol

5: LiAlH₄ / diethyl ether / Heating

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium acetate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;

DOI:10.1021/ja01067a026

upstream raw materials:

2-Chlor-3-phenyl-cyclobuten-⁽²⁾-ol

N-(3-phenylcyclobutylidene)isopropylamine

styrene

2,2-dichloro-1,1-difluoro-3-phenyl-cyclobutane

Downstream raw materials:

cis-3-phenylcyclobutanol tosylate

trans-3-phenylcyclobutanol tosylate

(1r,3r)-3-phenylcyclobutanol

Acetic acid 3-phenyl-cyclobutyl ester