Technology Process of 1-hydroxy-N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(1H-pyrazol-1-yl)pyridine-3-yl]methyl}-2-naphthamide
There total 6 articles about 1-hydroxy-N-[(1S,2S)-2-hydroxycyclohexyl]-4-{[6-(1H-pyrazol-1-yl)pyridine-3-yl]methyl}-2-naphthamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trans-N,N'-dimethyl-1,2-cyclohexyldiamine; caesium carbonate;
copper(l) iodide;
In
water; dimethyl sulfoxide;
at 120 ℃;
for 20h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine / acetic acid / 72 h
2.1: potassium carbonate / acetone / 14 h / 20 °C / Reflux
3.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 90 °C / Inert atmosphere
4.1: water; sodium hydroxide / tetrahydrofuran / 4 h / 90 °C
4.2: 20 °C
5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 3 h
6.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; caesium carbonate / copper(l) iodide / water; dimethyl sulfoxide / 20 h / 120 °C / Inert atmosphere
With
trans-N,N'-dimethyl-1,2-cyclohexyldiamine; water; bromine; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; sodium hydroxide;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; acetic acid; dimethyl sulfoxide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 90 °C / Inert atmosphere
2.1: water; sodium hydroxide / tetrahydrofuran / 4 h / 90 °C
2.2: 20 °C
3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 3 h
4.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; caesium carbonate / copper(l) iodide / water; dimethyl sulfoxide / 20 h / 120 °C / Inert atmosphere
With
trans-N,N'-dimethyl-1,2-cyclohexyldiamine; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; sodium hydroxide;
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
