4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide

Base Information

Chemical Name:4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide
CAS No.:1124320-61-1
Molecular Formula:C₂₀H₁₉N₅O₃S
Molecular Weight:409.469
Hs Code.:

Synonyms:4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide

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Chemical Property of 4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide

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Technology Process of 4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide

There total 4 articles about 4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1124321-37-4
4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1124320-61-1
4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere; Sealed tube;
DOI:10.1021/ml400095m

Reference yield: 10.0%

: 1124321-37-4
4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1124320-61-1
4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide

Guidance literature:: With sodium carbonate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; In water; N,N-dimethyl-formamide; at 130 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 85333-43-3
8-chloro-2-methyl-imidazo[1,2-a]pyrazine

: 1124320-61-1
4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / dichloromethane / 2.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 2-methyl-propan-1-ol / 16 h / 108 °C

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; caesium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 2-methyl-propan-1-ol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml400095m