2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester

Base Information

Chemical Name:2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester
CAS No.:331000-86-3
Molecular Formula:C₃₈H₃₂FNO₆S
Molecular Weight:649.74
Hs Code.:

2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester

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Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester

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Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester

There total 7 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

: 331000-86-3
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / I₂; PhI(OAc)2

2: 82 percent / MsCl; Et₃N / CH₂Cl₂ / 24 h / 0 °C

3: 70 percent / Et₃N / tetrahydrofuran / 18 h

4: 95 percent / mCPBA / CH₂Cl₂ / 2 h / -40 °C

5: 70 percent / DAST; SbCl₃ / CH₂Cl₂ / 4 h / 20 °C

6: mCPBA / CH₂Cl₂ / 1.5 h / -20 - -5 °C

With [bis(acetoxy)iodo]benzene; iodine; antimony(III) chloride; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; In tetrahydrofuran; dichloromethane; 3: Michael addition;
DOI:10.1021/ol006997s

Reference yield:

: 331000-85-2
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-phenylsulfanyl)-propionic acid benzhydryl ester

: 331000-86-3
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -20 - -5 ℃; for 1.5h;
DOI:10.1021/ol006997s

Reference yield:

: 5350-57-2
benzophenone hydrazone

: 331000-86-3
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-(4-methoxy-benzenesulfinyl)-propionic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / I₂; PhI(OAc)2

2: 82 percent / MsCl; Et₃N / CH₂Cl₂ / 24 h / 0 °C

3: 70 percent / Et₃N / tetrahydrofuran / 18 h

4: 95 percent / mCPBA / CH₂Cl₂ / 2 h / -40 °C

5: 70 percent / DAST; SbCl₃ / CH₂Cl₂ / 4 h / 20 °C

6: mCPBA / CH₂Cl₂ / 1.5 h / -20 - -5 °C

With [bis(acetoxy)iodo]benzene; iodine; antimony(III) chloride; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; In tetrahydrofuran; dichloromethane; 3: Michael addition;
DOI:10.1021/ol006997s