N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine

Base Information

Chemical Name:N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine
CAS No.:81816-77-5
Molecular Formula:C₂₁H₂₆N₂O₃*2ClH
Molecular Weight:427.371
Hs Code.:

N<sup>1</sup>-(6-hydroxymethyl-4-chromanyl)-N<sup>4</sup>-(p-methoxyphenyl)piperazine

Synonyms:N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine

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Chemical Property of N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine

Chemical Property:

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Technology Process of N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine

There total 8 articles about N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 81816-75-3
4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-chroman-6-carboxylic acid ethyl ester

: 81816-77-5
N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 3h; Heating;

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 81816-77-5
N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 8 steps

1: 38 percent / potassium hydroxide / H₂O / 4 h / 80 - 90 °C

2: 60 percent / phosphorous pentoxide / benzene / 10 h / Heating

3: 70 percent / hydroxylamine hydrochloride, potassium carbonate / ethanol / 6 h / Heating

4: 80 percent / hydrogene / Raney nickel / ethanol

5: 68.8 percent / ethanol / 2 h / Ambient temperature

6: 86 percent / thionyl chloride / CHCl₃ / 1.) 0 deg C, 2.) room temperature, 24 h

7: sodium iodide, sodium carbonate / butan-1-ol / 6 h / Heating

8: 98 percent / LAH / tetrahydrofuran; diethyl ether / 3 h / Heating

With phosphorus pentaoxide; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydroxylamine hydrochloride; hydrogen; sodium carbonate; potassium carbonate; sodium iodide; nickel; In tetrahydrofuran; diethyl ether; ethanol; chloroform; water; butan-1-ol; benzene;

Reference yield:

: 81816-56-0
6-carbethoxychromanone

: 81816-77-5
N¹-(6-hydroxymethyl-4-chromanyl)-N⁴-(p-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / hydroxylamine hydrochloride, potassium carbonate / ethanol / 6 h / Heating

2: 80 percent / hydrogene / Raney nickel / ethanol

3: 68.8 percent / ethanol / 2 h / Ambient temperature

4: 86 percent / thionyl chloride / CHCl₃ / 1.) 0 deg C, 2.) room temperature, 24 h

5: sodium iodide, sodium carbonate / butan-1-ol / 6 h / Heating

6: 98 percent / LAH / tetrahydrofuran; diethyl ether / 3 h / Heating

With lithium aluminium tetrahydride; thionyl chloride; hydroxylamine hydrochloride; hydrogen; sodium carbonate; potassium carbonate; sodium iodide; nickel; In tetrahydrofuran; diethyl ether; ethanol; chloroform; butan-1-ol;