Technology Process of C56H65BrCl4N8O13Si
There total 39 articles about C56H65BrCl4N8O13Si which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Boc-Ise(TBDPS)-Trp(5-Br)-OH;
With
((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V);
In
2,4,6-trimethyl-pyridine; N,N-dimethyl-formamide;
for 0.0833333h;
Iinert atmosphere;
Cooling with ice;
C21H25Cl4N5O8;
In
2,4,6-trimethyl-pyridine; N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
Cooling with ice;
DOI:10.1021/ol300576n
- Guidance literature:
-
Boc-Ise(TBDPS)-Trp(5-Br)-OH;
With
1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 1h;
Cooling with ice;
Inert atmosphere;
C21H25Cl4N5O8;
In
2,4,6-trimethyl-pyridine; N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol300576n
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1H-imidazole; dmap / dichloromethane / Inert atmosphere
2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C / Cooling with ice; Inert atmosphere
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 0 °C / Inert atmosphere
4.1: dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C / Cooling with ice
6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C / Cooling with ice; Inert atmosphere
6.2: 0 - 20 °C / Inert atmosphere
With
1H-imidazole; dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol300576n
