Technology Process of N'-hydroxy-2-methylpyridine-4-carboxamidine
There total 2 articles about N'-hydroxy-2-methylpyridine-4-carboxamidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfuric acid / 18 h / 70 °C
2: ammonia / methanol / 20 h / 60 °C / Sealed
3: trifluoroacetic anhydride; pyridine / dichloromethane / 2 h / 0 °C
4: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 16 h / 60 °C / Sealed
With
pyridine; sulfuric acid; hydroxylamine hydrochloride; ammonia; sodium hydrogencarbonate; trifluoroacetic anhydride;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic anhydride; pyridine / dichloromethane / 2 h / 0 °C
2: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 16 h / 60 °C / Sealed
With
pyridine; hydroxylamine hydrochloride; sodium hydrogencarbonate; trifluoroacetic anhydride;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 100 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; HATU / dimethylsulfoxide-d6 / 2 h / 20 °C
With
N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
dimethylsulfoxide-d6; dichloromethane; N,N-dimethyl-formamide;
