4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester

Base Information

• Chemical Name: 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester
• CAS No.: 865266-05-3
• Molecular Formula: C₃₁H₃₃Cl₂NO₈S
• Molecular Weight: 650.577

Synonyms:4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester

Chemical Property of 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester

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Technology Process of 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester

There total 1 articles about 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ol (53560-34-2) → 4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester (865266-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / pyridinium dichlorochromate / CH₂Cl₂ / 1 h / 20 °C

2: 95 percent / tetrahydrofuran / 1 h / 20 °C

3: 43 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; dicyclohexyl-carbodiimide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1007/s00706-005-0281-3

Reference yield: 84.0%

4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester (865266-05-3) → (S)-(-)-4-(3,4,5-trimethoxyphenyl)-3-butyn-2-ol (865266-07-5)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃;

DOI:10.1007/s00706-005-0281-3

Reference yield:

4,5-Dichloro-2-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-benzoic acid (S)-1-methyl-3-(3,4,5-trimethoxy-phenyl)-prop-2-ynyl ester (865266-05-3) → (2S)-(+)-4-(3,4,5-trimethoxyphenyl)-3-butyn-2-yl 4-methoxybenzoate

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / K₂CO₃ / methanol / 20 °C

2: 87 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1007/s00706-005-0281-3

upstream raw materials:

3-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ol

Downstream raw materials:

(S)-(-)-4-(3,4,5-trimethoxyphenyl)-3-butyn-2-ol

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