4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide

Base Information

Chemical Name:4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide
CAS No.:1263131-91-4
Molecular Formula:C₃₀H₂₇FN₄O₅
Molecular Weight:542.567
Hs Code.:

Synonyms:4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide

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Chemical Property of 4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide

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Technology Process of 4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide

There total 6 articles about 4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1359944-42-5
4'-fluoro-N-(3-((3,4,5-trimethoxybenzoyl)aminocarbonothioylamino)phenyl)biphenyl-4-carboxamide

: 1263131-91-4
4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere; Cooling with ice;
DOI:10.1021/jm2013369

Reference yield:

: 1359944-70-9
C₁₉H₁₃FN₂O₃

: 1263131-91-4
4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; tin(II) chloride hydrate / ethanol / 60 °C / Inert atmosphere

2: acetone / 1 h / Inert atmosphere; Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; tin(II) chloride hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In ethanol; acetone; acetonitrile;
DOI:10.1021/jm2013369

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 1263131-91-4
4'-fluoro-N-(3-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)biphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 0.33 h / Inert atmosphere; Reflux

2: acetone / 1 h / Inert atmosphere; Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetone; acetonitrile;
DOI:10.1021/jm2013369