(S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate

Base Information

Chemical Name:(S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate
CAS No.:1380754-50-6
Molecular Formula:C₂₅H₂₃ClFN₃O₄
Molecular Weight:483.927
Hs Code.:

Synonyms:(S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate

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Chemical Property of (S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate

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Technology Process of (S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate

There total 4 articles about (S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84499-77-4
(S)-α-(p-bromophenyl)ethylamine hydrochloride

: 1380754-50-6
(S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / 80 °C

3.1: hydrogenchloride / ethyl acetate / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / dichloromethane / 1 h / 20 °C

4.2: 20 °C

With hydrogenchloride; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1380753-75-2
5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinic acid

: methyl (S)-4-(1-aminoethyl)benzoate hydrochloride

: 1380754-50-6
(S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate

Guidance literature:: 5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinic acid; With 1-hydroxy-1H-benzotriazol hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

methyl (S)-4-(1-aminoethyl)benzoate hydrochloride; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 847728-89-6
(S)-tert-butyl (1-(4-bromophenyl)ethyl)carbamate

: 1380754-50-6
(S)-methyl 4-(1-(5-chloro-2-(3-(4-fluorophenoxy)azetidin-1-yl)nicotinamido)ethyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / 80 °C

2.1: hydrogenchloride / ethyl acetate / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / dichloromethane / 1 h / 20 °C

3.2: 20 °C

With hydrogenchloride; 1-hydroxy-1H-benzotriazol hydrate; 1,3-bis-(diphenylphosphino)propane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;