methyl 6a-bromo-11a-cyano-7-(2-methoxy-2-oxoethyl)-5,6a,7,7a,8,9,10,11a-octahydro-6H-benzo[g]pyrrolo[1,2-a]indole-7-carboxylate

Base Information

• Chemical Name: methyl 6a-bromo-11a-cyano-7-(2-methoxy-2-oxoethyl)-5,6a,7,7a,8,9,10,11a-octahydro-6H-benzo[g]pyrrolo[1,2-a]indole-7-carboxylate
• CAS No.: 83927-37-1
• Molecular Formula: C₂₁H₂₃BrN₂O₄
• Molecular Weight: 447.329
• Mol file: 83927-37-1.mol

Synonyms:

Chemical Property of methyl 6a-bromo-11a-cyano-7-(2-methoxy-2-oxoethyl)-5,6a,7,7a,8,9,10,11a-octahydro-6H-benzo[g]pyrrolo[1,2-a]indole-7-carboxylate

Chemical Property:

• Vapor Pressure: 2.93E-11mmHg at 25°C
• Boiling Point: 528.6°Cat760mmHg
• Flash Point: 273.5°C
• Density: 1.49g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6a-bromo-11a-cyano-7-(2-methoxy-2-oxoethyl)-5,6a,7,7a,8,9,10,11a-octahydro-6H-benzo[g]pyrrolo[1,2-a]indole-7-carboxylate

There total 1 articles about methyl 6a-bromo-11a-cyano-7-(2-methoxy-2-oxoethyl)-5,6a,7,7a,8,9,10,11a-octahydro-6H-benzo[g]pyrrolo[1,2-a]indole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

bromocyane (506-68-3) + 5,7,7a,8,9,10-hexahydro-7-methoxycarbonyl-6H-benzopyrrolo<1,2-a>indole-7-acetic acid methyl ester (67395-21-5) → 6a-bromo-7-carboxy-11a-cyano-5,6a,7,7a,8,9,10,11a-octahydro-6H-benzopyrrolo<1,2-a>indole-7-acetic acid dimethyl ester (83927-37-1)

Guidance literature:

With magnesium oxide; In tetrahydrofuran; water; for 1h; Ambient temperature;

DOI:10.1016/0040-4020(82)80259-7

Reference yield:

6a-bromo-7-carboxy-11a-cyano-5,6a,7,7a,8,9,10,11a-octahydro-6H-benzopyrrolo<1,2-a>indole-7-acetic acid dimethyl ester (83927-37-1) → 7-carboxy-7a,8,9,10-tetrahydro-7H-benzopyrrolo<1,2-a>indole-7-acetic acid dimethyl ester (83927-38-2)

Guidance literature:

With silica gel; In chloroform; for 24h; Yield given; Ambient temperature;

DOI:10.1016/0040-4020(82)80259-7

Reference yield:

6a-bromo-7-carboxy-11a-cyano-5,6a,7,7a,8,9,10,11a-octahydro-6H-benzopyrrolo<1,2-a>indole-7-acetic acid dimethyl ester (83927-37-1) → 7-carboxy-7a,8,9,10-tetrahydro-4-(trifluoroacetyl)-7H-benzopyrrolo<1,2-a>indole-7-acetic acid dimethyl ester (83927-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: silica gel / CHCl₃ / 24 h / Ambient temperature

2: 78 percent / 2 h / Heating

With silica gel; In chloroform;

DOI:10.1016/0040-4020(82)80259-7

upstream raw materials:

bromocyane

5,7,7a,8,9,10-hexahydro-7-methoxycarbonyl-6H-benzopyrrolo<1,2-a>indole-7-acetic acid methyl ester

Downstream raw materials:

7-carboxy-7a,8,9,10-tetrahydro-7H-benzopyrrolo<1,2-a>indole-7-acetic acid dimethyl ester

2-(3-bromopropyl)-3-carboxy-1-cyanobenzindoline-3-acetic acid dimethyl ester

7-carboxy-7a,8,9,10-tetrahydro-4-(trifluoroacetyl)-7H-benzopyrrolo<1,2-a>indole-7-acetic acid dimethyl ester