7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester

Base Information

Chemical Name:7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester
CAS No.:355823-54-0
Molecular Formula:C₂₆H₃₃ClN₃O₉PS₂
Molecular Weight:662.121
Hs Code.:

Synonyms:7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester

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Chemical Property of 7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester

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Technology Process of 7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester

There total 9 articles about 7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57-66-9
4-[(dipropylamino)sulfonyl]benzoic acid

: 355823-54-0
7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / Heating

2: DBU / tetrahydrofuran / 1 h

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;
DOI:10.1016/S0014-827X(02)01281-8

Reference yield:

: 34170-81-5
diethyl (2-chloro-2-oxoethyl)phosphonate

: 355823-54-0
7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 53 percent / pyridine / toluene / 0.75 h / 20 °C

2.1: 73 percent / piperidine / toluene / 8 h / Heating

3.1: 80 percent / H₂SO₄; HNO₃ / 0.25 h / 5 °C

4.1: 73 percent / Fe; aq. NH₄Cl / methanol / 1 h / Heating

5.1: NaNO₂; glac. AcOH; aq. HCl / 0.5 h / 5 °C

5.2: 91 percent / SO₂; CuCl₂*2H₂O; aq. AcOH / 4 h / 0 - 20 °C

6.1: 78 percent / aq. ammonia / 1 h / 20 °C

7.1: DBU / tetrahydrofuran / 1 h

With piperidine; pyridine; hydrogenchloride; ammonium hydroxide; sulfuric acid; nitric acid; iron; ammonium chloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium nitrite; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/S0014-827X(02)01281-8

Reference yield:

: 59236-37-2
2-amino-4-chlorobenzaldehyde

: 355823-54-0
7-Chloro-6-[({4-[(dipropylamino)sulphonyl]benzoyl}amino)sulphonyl]-2-oxo-1,2-dihydro-3-quinolylphosphonic Acid Diethyl Ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 53 percent / pyridine / toluene / 0.75 h / 20 °C

2.1: 73 percent / piperidine / toluene / 8 h / Heating

3.1: 80 percent / H₂SO₄; HNO₃ / 0.25 h / 5 °C

4.1: 73 percent / Fe; aq. NH₄Cl / methanol / 1 h / Heating

5.1: NaNO₂; glac. AcOH; aq. HCl / 0.5 h / 5 °C

5.2: 91 percent / SO₂; CuCl₂*2H₂O; aq. AcOH / 4 h / 0 - 20 °C

6.1: 78 percent / aq. ammonia / 1 h / 20 °C

7.1: DBU / tetrahydrofuran / 1 h

With piperidine; pyridine; hydrogenchloride; ammonium hydroxide; sulfuric acid; nitric acid; iron; ammonium chloride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium nitrite; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/S0014-827X(02)01281-8