3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide

Base Information

Chemical Name:3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide
CAS No.:1192021-72-9
Molecular Formula:C₁₃H₇ClF₄N₂O₂
Molecular Weight:334.657
Hs Code.:

Synonyms:3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide

Chemical Property:

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Technology Process of 3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide

There total 4 articles about 3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 895128-46-8
3-chloroisonicotinoyl chloride

: 117338-13-3
2-amino-5-chloro-4-(trifluoromethyl)phenol

: 1192021-72-9
3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 2h; Cooling with ice;

Reference yield:

: 88912-27-0
3-chloro-isonicotinic acid

: 1192021-72-9
3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3.5 h / Reflux

2: triethylamine / N,N-dimethyl-formamide / 5 h / 50 °C / Cooling with ice

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 5-chloro-2-nitro-4-(trifluoromethyl)phenol

: 1192021-72-9
3-chloro-N-[4-fluoro-2-hydroxy-5-(trifluoromethyl)phenyl]-isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; iron / ethyl acetate; water / 0.5 h / 80 °C

2: triethylamine / N,N-dimethyl-formamide / 2 h / 20 - 50 °C / Cooling with ice

With iron; acetic acid; triethylamine; In water; ethyl acetate; N,N-dimethyl-formamide;