(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Base Information

Chemical Name:(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione
CAS No.:1614249-64-7
Molecular Formula:C₂₂H₂₂N₄O₂S
Molecular Weight:406.508
Hs Code.:

Synonyms:(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

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Chemical Property of (R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

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Technology Process of (R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

There total 3 articles about (R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1614249-62-5
1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-63-6
(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-64-7
(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: With Chiralpak ID column; In carbon dioxide; isopropyl alcohol; Resolution of racemate; liquid CO₂;

Reference yield:

: 1614252-48-0
trifluoro-methanesulfonic acid 2,4-dimethyl-1,3-dioxo-9-phenyl-1,2,3,4,7,8-hexahydro-2,4,8a-triaza-fluoren-5-yl ester

: 1614249-63-6
(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-64-7
(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

2: ammonium formate; hydrogen; palladium on activated charcoal / ethanol / 48 h / 60 °C

3: Chiralpak ID column / carbon dioxide; isopropyl alcohol / Resolution of racemate; liquid CO₂

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; palladium on activated charcoal; hydrogen; ammonium formate; lithium chloride; In tetrahydrofuran; ethanol; carbon dioxide; isopropyl alcohol;

Reference yield:

: 1614251-41-0
1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8-dihydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-63-6
(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-64-7
(R)-1,3-dimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate; hydrogen; palladium on activated charcoal / ethanol / 48 h / 60 °C

2: Chiralpak ID column / carbon dioxide; isopropyl alcohol / Resolution of racemate; liquid CO₂

With palladium on activated charcoal; hydrogen; ammonium formate; In ethanol; carbon dioxide; isopropyl alcohol;