N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide

Base Information

Chemical Name:N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide
CAS No.:872090-98-7
Molecular Formula:C₂₆H₂₁BrN₄O₂
Molecular Weight:501.382
Hs Code.:

Synonyms:N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide

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Chemical Property of N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide

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Technology Process of N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide

There total 7 articles about N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 872091-00-4
3-(1-cyano-1-methylethyl)benzoic acid

: 872090-99-8
3-(5-amino-2-methylphenyl)-6-bromo-3H-quinazolin-4-one

: 872090-98-7
N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 25 ℃; for 72h;

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 872090-98-7
N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / toluene / 3 h / Heating / reflux

1.2: 20 h / 40 °C / Heating / reflux

2.1: hydrogenchloride; water / 6 h / Heating / reflux

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 12 h / Heating / reflux

4.1: water; hydrogen bromide; acetic acid / 24 h / 25 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 72 h / 25 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; hydrogen bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; acetic acid; In DMF (N,N-dimethyl-formamide); toluene;

Reference yield:

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 872090-98-7
N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / toluene / 3 h / Heating / reflux

1.2: 20 h / 40 °C / Heating / reflux

2.1: hydrogenchloride; water / 6 h / Heating / reflux

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 12 h / Heating / reflux

4.1: water; hydrogen bromide; acetic acid / 24 h / 25 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 72 h / 25 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; hydrogen bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; acetic acid; In DMF (N,N-dimethyl-formamide); toluene;