(E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate

Base Information

Chemical Name:(E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate
CAS No.:1444002-56-5
Molecular Formula:C₂₂H₂₂O₆
Molecular Weight:382.413
Hs Code.:

Synonyms:(E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate

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Chemical Property of (E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate

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Technology Process of (E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate

There total 4 articles about (E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3328-73-2
4-hydroxy-5-methylisophthalaldehyde

: 96928-09-5
ethyl 2-(4-acetylphenoxy)-propanoate

: 1444002-56-5
(E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; regioselective reaction; Reflux;
DOI:10.1016/j.ejmech.2013.04.026

Reference yield:

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 1444002-56-5
(E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 4 h / 90 °C

2: hydrogenchloride / 1,4-dioxane / Reflux

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; acetonitrile;
DOI:10.1016/j.ejmech.2013.04.026

Reference yield:

: 95-48-7,77504-84-8
ortho-cresol

: 1444002-56-5
(E)-ethyl 2-(4-(3-(3-formyl-4-hydroxy-5-methylphenyl) acryloyl) phenoxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 3 h / 120 °C

1.2: 2 h / 90 - 100 °C

2.1: hydrogenchloride / 1,4-dioxane / Reflux

With hydrogenchloride; In 1,4-dioxane; trifluoroacetic acid; 1.1: |Duff Aldehyde Synthesis / 1.2: |Duff Aldehyde Synthesis;
DOI:10.1016/j.ejmech.2013.04.026