Technology Process of C22H29N2O3P
There total 4 articles about C22H29N2O3P which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
nitromethane;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.75h;
Inert atmosphere;
C21H26NOP;
In
tetrahydrofuran;
at -78 ℃;
for 8h;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1111/j.1747-0285.2010.01047.x
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium(IV) isopropylate; triethylamine / toluene / Inert atmosphere; Reflux
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
2.2: 8 h / -78 °C / Inert atmosphere
With
titanium(IV) isopropylate; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
2.1: Henry reaction / 2.2: Henry reaction;
DOI:10.1111/j.1747-0285.2010.01047.x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere
2.1: ammonia / dichloromethane / 12 h / -78 - 20 °C
3.1: titanium(IV) isopropylate; triethylamine / toluene / Inert atmosphere; Reflux
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
4.2: 8 h / -78 °C / Inert atmosphere
With
titanium(IV) isopropylate; oxalyl dichloride; ammonia; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; toluene;
4.1: Henry reaction / 4.2: Henry reaction;
DOI:10.1111/j.1747-0285.2010.01047.x
