10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester

Base Information

Chemical Name:10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester
CAS No.:1609262-54-5
Molecular Formula:C₂₈H₂₄N₂O₅
Molecular Weight:468.509
Hs Code.:

Synonyms:10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester

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Chemical Property of 10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester

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Technology Process of 10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester

There total 3 articles about 10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1609262-27-2
1-(2-bromophenyl)-3-(4-methoxyphenyl)-2-[2-(4-methoxyphenyl)vinyl]-6-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylic acid dimethyl ester

: 1609262-54-5
10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester

Guidance literature:: With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tet.2014.04.023

Reference yield:

: 37881-46-2,56110-15-7
(4-methoxyphenyl)-[3-(4-methoxyphenyl)-allylidene]-amine

: 1609262-54-5
10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 12 h / 20 °C

2: potassium carbonate; palladium diacetate; triphenylphosphine; tetrabutyl-ammonium chloride / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; acetonitrile; 2: |Heck Reaction;
DOI:10.1016/j.tet.2014.04.023

Reference yield:

: 1592-00-3
2-bromophenyl isocyanate

: 1609262-54-5
10-(4-methoxybenzyl)-1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 12 h / 20 °C

2: potassium carbonate; palladium diacetate; triphenylphosphine; tetrabutyl-ammonium chloride / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; acetonitrile; 2: |Heck Reaction;
DOI:10.1016/j.tet.2014.04.023