N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Base Information

Chemical Name:N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide
CAS No.:1307271-34-6
Molecular Formula:C₂₂H₂₆ClN₅O₃S₂
Molecular Weight:508.065
Hs Code.:

Synonyms:N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Chemical Property of N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Technology Process of N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

There total 5 articles about N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1307272-03-2
N-{2-chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

: 1307271-34-6
N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: With ammonium hydroxide; In water; at 90 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1307271-97-1
4-methyltetrahydro-2H-pyran-4-carbothioamide

: 1307271-34-6
N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 20 °C / Inert atmosphere

1.2: 0.67 h / 80 °C / Inert atmosphere

2.1: tri-n-butyl-tin hydride; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 36 h / 0 - 5 °C / Inert atmosphere

4.1: ammonium hydroxide / water / 2 h / 90 °C / Inert atmosphere; Microwave irradiation

With pyridine; ammonium hydroxide; N-Bromosuccinimide; water; tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; ISOPROPYLAMIDE; water;

Reference yield:

: 1307272-38-3
4-methyltetrahydro-2H-pyran-4-carboxamide

: 1307271-34-6
N-{2-chloro-3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Lawessons reagent / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

2.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 20 °C / Inert atmosphere

2.2: 0.67 h / 80 °C / Inert atmosphere

3.1: tri-n-butyl-tin hydride; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 36 h / 0 - 5 °C / Inert atmosphere

5.1: ammonium hydroxide / water / 2 h / 90 °C / Inert atmosphere; Microwave irradiation

With Lawessons reagent; pyridine; ammonium hydroxide; N-Bromosuccinimide; water; tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; water;