cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide

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Chemical Name:cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide
CAS No.:1190379-43-1
Molecular Formula:C₂₅H₃₆N₆O
Molecular Weight:436.6
Hs Code.:

Synonyms:cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide

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Chemical Property of cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide

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Technology Process of cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide

There total 8 articles about cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1190379-94-2
cyclobutanecarboxylic acid [3-(2-chloro-5-cyclopropyl-pyrimidin-4-ylamino)-propyl]-amide

: 5636-52-2
4-[2-(dimethylamino)ethyl]aniline

: 1190379-43-1
cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; Inert atmosphere;

Reference yield:

: 59698-21-4
5-cyclopropyl-2-thio-2,3-dihydropyrimidine-2,4(1H,3H)-dione

: 1190379-43-1
cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 0 - 90 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 - 55 °C / Cooling with ice

3: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; sodium t-butanolate; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; isopropyl alcohol;

Reference yield:

: 1190379-86-2
2,4-dichloro-5-cyclopropylpyrimidine

: 1190379-43-1
cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 - 55 °C / Cooling with ice

2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; isopropyl alcohol;