(R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide

Base Information

Chemical Name:(R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide
CAS No.:1449335-35-6
Molecular Formula:C₂₃H₂₁N₃O₂
Molecular Weight:371.439
Hs Code.:

Synonyms:(R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide

Chemical Property:

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Technology Process of (R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide

There total 5 articles about (R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 1381947-81-4
methyl 3-(1H-benzo[d]imidazol-1-yl)-benzoate

: 1449335-35-6
(R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide

Guidance literature:: With caesium carbonate; In toluene; at 85 ℃;
DOI:10.1055/s-0033-1338848

Reference yield:

: 4518-10-9
Methyl 3-aminobenzoate

: 1449335-35-6
(R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / toluene / 16 h / 75 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 60 °C / 760.05 Torr / Reflux

3: toluene-4-sulfonic acid / 12 h / 100 °C

4: caesium carbonate / toluene / 85 °C

With palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; bis[2-(diphenylphosphino)phenyl] ether; In methanol; toluene;
DOI:10.1055/s-0033-1338848

Reference yield:

: 1189178-13-9
3-[(2-nitrophenyl)amino]benzoic acid methyl ester

: 1449335-35-6
(R)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3-phenylpropan-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 60 °C / 760.05 Torr / Reflux

2: toluene-4-sulfonic acid / 12 h / 100 °C

3: caesium carbonate / toluene / 85 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; toluene-4-sulfonic acid; In methanol; toluene;
DOI:10.1055/s-0033-1338848