4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile

Base Information

Chemical Name:4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile
CAS No.:1449474-08-1
Molecular Formula:C₂₃H₁₇FN₄
Molecular Weight:368.413
Hs Code.:

Synonyms:4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile

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Chemical Property of 4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile

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Technology Process of 4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile

There total 3 articles about 4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1449475-57-3
C₂₈H₂₅FN₄O₂

: 1449474-08-1
4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 71066-00-7
2-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid

: 1449474-08-1
4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide; toluene / -20 °C

1.2: 18 h / 20 °C

1.3: 2 h / 60 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 2 h

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trifluoroacetic acid; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1449474-08-1
4-[2-(2-amino-2,3-dihydro-1H-inden-2-yl)-1H-benzimidazol-5-yl]-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide; toluene / -20 °C

1.2: 18 h / 20 °C

1.3: 2 h / 60 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 2 h

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trifluoroacetic acid; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;