benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate
CAS No.:1421049-57-1
Molecular Formula:C₂₈H₃₉N₃O₇
Molecular Weight:529.634
Hs Code.:

Synonyms:benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

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Chemical Property of benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

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Technology Process of benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

There total 4 articles about benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 1421049-51-5
(2S,3S)-N-isobutyl-2,3-dimethoxy-3-(2-nitrophenyl)propan-1-amine

: 1421049-57-1
benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 6h;
DOI:10.1021/ol3032126

Reference yield:

: 1421049-48-0
1-((1S,2S)-3-azido-1,2-dimethoxypropyl)-2-nitrobenzene

: 1421049-57-1
benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; water / tetrahydrofuran / 24 h / 20 °C

2: ethanol / 0.5 h

3: sodium cyanoborohydride; acetic acid / ethanol / 1 h / 0 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 0 °C

With water; sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: |Staudinger Azide Reduction;
DOI:10.1021/ol3032126

Reference yield:

: C₁₅H₂₂N₂O₄

: 1421049-57-1
benzyl (S)-1-(((2S,3S)-2,3-dimethoxy-3-(2-nitrophenyl) propyl) (isobutyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / ethanol / 1 h / 0 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 0 °C

With sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ol3032126