3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

Base Information

Chemical Name:3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid
CAS No.:872513-45-6
Molecular Formula:C₂₆H₂₈F₂N₄O₄Si
Molecular Weight:526.615
Hs Code.:

Synonyms:3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

Suppliers and Price of 3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

There total 7 articles about 3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 872513-26-3
3-[6-chloro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 872513-45-6
3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

Guidance literature:: With (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triphenylphosphine; sodium t-butanolate; palladium diacetate; In 1,4-dioxane; for 0.25h; Heating;
DOI:10.1016/j.bmcl.2005.10.015

Reference yield:

: 872513-52-5
(5-bromo-2-methoxy-phenyl)-(2,6-dichloro-pyridin-3-yl)-methanol

: 872513-45-6
3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 79 percent / CrO₃; aq. H₂SO₄ / acetone

2.1: 70 percent / hydrazine hydrate / ethanol; butan-1-ol / 1 h / Heating

3.1: KN(TMS)2 / tetrahydrofuran / -78 °C

4.1: n-BuLi / tetrahydrofuran

4.2: 63 percent / tetrahydrofuran

5.1: 96 percent / PPh₃; NaOtBu; R-(+)-BINAP / Pd(OAc)2 / dioxane / 0.25 h / Heating

With chromium(VI) oxide; n-butyllithium; sulfuric acid; potassium hexamethylsilazane; hydrazine hydrate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triphenylphosphine; sodium t-butanolate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; acetone; butan-1-ol; 1.1: Jones oxidation / 5.1: Buchwald reaction;
DOI:10.1016/j.bmcl.2005.10.015

Reference yield:

: 872513-21-8
(5-bromo-2-methoxy-phenyl)-(2,6-dichloro-pyridin-3-yl)-methanone

: 872513-45-6
3-[6-(2,4-difluoro-phenylamino)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methoxy-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 70 percent / hydrazine hydrate / ethanol; butan-1-ol / 1 h / Heating

2.1: KN(TMS)2 / tetrahydrofuran / -78 °C

3.1: n-BuLi / tetrahydrofuran

3.2: 63 percent / tetrahydrofuran

4.1: 96 percent / PPh₃; NaOtBu; R-(+)-BINAP / Pd(OAc)2 / dioxane / 0.25 h / Heating

With n-butyllithium; potassium hexamethylsilazane; hydrazine hydrate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triphenylphosphine; sodium t-butanolate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; butan-1-ol; 4.1: Buchwald reaction;
DOI:10.1016/j.bmcl.2005.10.015