Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate

Base Information

• Chemical Name: Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate
• CAS No.: 89088-15-3
• Molecular Formula: C₂₈H₃₅N₃O₆
• Molecular Weight: 509.602

Synonyms:Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate

Chemical Property of Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate

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Technology Process of Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate

There total 3 articles about Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tyrosamine (51-67-2) → Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate (89088-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / DIPEA / ethyl acetate / 20 h / 25 °C

2: 1. thallium ethoxide / 1. ether, 25 deg C, 2. a. DMF, 1h, 25 deg C, b. 20h, -15 deg C

With thallium (I) ethoxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate;

DOI:10.1021/jo00180a011

Reference yield:

(tert-butoxycarbonyl)-L-phenylalanine N-hydroxysuccinimide ester (3674-06-4,3674-18-8,74124-84-8) → Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate (89088-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / DIPEA / ethyl acetate / 20 h / 25 °C

2: 1. thallium ethoxide / 1. ether, 25 deg C, 2. a. DMF, 1h, 25 deg C, b. 20h, -15 deg C

With thallium (I) ethoxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate;

DOI:10.1021/jo00180a011

Reference yield:

3-Brom-1-pyrrolin-2-carbonsaeure-methylester (72978-15-5) + N-(tert-Butoxycarbonyl)-L-phenyl-alanyltyramide (89088-14-2) → Methyl 3-amino>ethyl>phenoxy>-1-pyrroline-2-carboxylate (89088-15-3)

Guidance literature:

With thallium (I) ethoxide; Multistep reaction. Title compound not separated from byproducts; 1. ether, 25 deg C, 2. a. DMF, 1h, 25 deg C, b. 20h, -15 deg C;

DOI:10.1021/jo00180a011

upstream raw materials:

3-Brom-1-pyrrolin-2-carbonsaeure-methylester

N-(tert-Butoxycarbonyl)-L-phenyl-alanyltyramide

tyrosamine

(tert-butoxycarbonyl)-L-phenylalanine N-hydroxysuccinimide ester

Downstream raw materials:

(5S,8R,9R)-5-Benzyl-1,2-dihydro-N^α-(N,N-dimethyl-L-alanyl-L-valyl)-N^α,9-ethylene-p-phencyclopeptine

Dihydromauritine A

trans-β-amino>ethyl>phenoxy>proline

(2R,3R)-3-{4-[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-ethyl]-phenoxy}-1-[2-(2-dimethylamino-propionylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid

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