dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

Base Information

Chemical Name:dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane
CAS No.:112917-47-2
Molecular Formula:C₁₄H₁₇NO₃S
Molecular Weight:279.36
Hs Code.:

Synonyms:dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

Suppliers and Price of dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

There total 10 articles about dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112917-43-8
dl-(1α,2α,3β,5α)-2-(hydroxyethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

: 112917-47-2
dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -60 ℃; for 0.25h;
DOI:10.1021/jm00163a038

Reference yield:

: 49826-08-6,54483-54-4,54483-55-5,75331-67-8
1-hydroxy-2-(2-hydroxyethyl)cyclopent-3-ene

: 112917-47-2
dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 10 steps

1: 96 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / Ambient temperature

2: 40.9 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 0.25 h / Ambient temperature

3: 95 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 5 h / Heating

4: 1.) Zn-Ag couple, 2.) / 1.) ether, reflux, 2.) reflux, 4 h

5: PDC / dimethylformamide / 3 h / Ambient temperature

6: KOH, NH₂OH*HCl / methanol / 3 h / Ambient temperature

7: 1.) diphenyl disulfide, n-Bu₃P, 2.) sodium cyanoborohydride, acetic acid / 1.) THF, RT, 1 h, 2.) -70 deg C, 10 min

8: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

9: 80percent aq. AcOH / 15 h / Heating

10: oxalyl chloride/DMSO / CH₂Cl₂ / 0.25 h / -60 °C

With dmap; potassium hydroxide; dipyridinium dichromate; oxalyl dichloride; tributylphosphine; hydroxylamine hydrochloride; silver; sodium cyanoborohydride; sodium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; diphenyldisulfane; zinc; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a038

Reference yield:

: 112918-26-0
dl-trans-2-<2-(benzoyloxy)cyclopent-4-enyl>ethanol triphenylmethyl ether

: 112917-47-2
dl-(1α,2α,3β,5α)-2-(formylmethyl)-3-<(phenylsulfonyl)amino>bicyclo<3.1.0>hexane

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 5 h / Heating

2: 1.) Zn-Ag couple, 2.) / 1.) ether, reflux, 2.) reflux, 4 h

3: PDC / dimethylformamide / 3 h / Ambient temperature

4: KOH, NH₂OH*HCl / methanol / 3 h / Ambient temperature

5: 1.) diphenyl disulfide, n-Bu₃P, 2.) sodium cyanoborohydride, acetic acid / 1.) THF, RT, 1 h, 2.) -70 deg C, 10 min

6: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

7: 80percent aq. AcOH / 15 h / Heating

8: oxalyl chloride/DMSO / CH₂Cl₂ / 0.25 h / -60 °C

With potassium hydroxide; dipyridinium dichromate; oxalyl dichloride; tributylphosphine; hydroxylamine hydrochloride; silver; sodium cyanoborohydride; sodium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; diphenyldisulfane; zinc; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a038