N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride

Base Information

Chemical Name:N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride
CAS No.:1454666-73-9
Molecular Formula:C₂₅H₂₄F₃N₅O₂S*ClH
Molecular Weight:552.02
Hs Code.:

Synonyms:N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride

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Chemical Property of N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride

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Technology Process of N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride

There total 7 articles about N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454667-84-5
tert-butyl 4-(2-(2-(N-(pyrazin-2-yl)sulfamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1454666-73-9
N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 80 ℃; for 1h;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1454666-73-9
N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 3 h / 100 °C

1.2: 1 h / 100 °C

2.1: acetic acid; platinum(IV) oxide; hydrogen / methanol / 2327.23 Torr

3.1: sulfuryl dichloride; 1H-imidazole / N,N-dimethyl-formamide; dichloromethane / -10 °C

3.2: 0.33 h / 80 °C

4.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 1 h / 80 °C

With 1H-imidazole; hydrogenchloride; platinum(IV) oxide; potassium phosphate; sulfuryl dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 640280-28-0
1-bromo-2-iodo-4-(trifluoromethyl)benzene

: 1454666-73-9
N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 3 h / 100 °C

1.2: 1 h / 100 °C

2.1: acetic acid; platinum(IV) oxide; hydrogen / methanol / 2327.23 Torr

3.1: sulfuryl dichloride; 1H-imidazole / N,N-dimethyl-formamide; dichloromethane / -10 °C

3.2: 0.33 h / 80 °C

4.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 1 h / 80 °C

With 1H-imidazole; hydrogenchloride; platinum(IV) oxide; potassium phosphate; sulfuryl dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;