(S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine

Base Information

Chemical Name:(S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine
CAS No.:1429181-29-2
Molecular Formula:C₁₄H₁₉N₅
Molecular Weight:257.338
Hs Code.:

Synonyms:(S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine

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Chemical Property of (S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine

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Technology Process of (S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine

There total 5 articles about (S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429181-28-1
(S)-tert-butyl 1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)ethylcarbamate

: 1429181-29-2
(S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at -78 - 20 ℃; for 1h;

Reference yield:

: 222714-37-6
4-[(1S)-1-aminoethyl]-benzoic acid, methyl ester

: 1429181-29-2
(S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 16 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 20 °C

3: methanesulfonyl chloride; triethylamine / dichloromethane / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 80 °C

5: trifluoroacetic acid / dichloromethane / 1 h / -78 - 20 °C

With lithium aluminium tetrahydride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 847728-90-9
(S)-methyl 4-(1-((tert-butoxycarbonyl)amino)ethyl)benzoate

: 1429181-29-2
(S)-1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)thanamine

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 20 °C

2: methanesulfonyl chloride; triethylamine / dichloromethane / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 80 °C

4: trifluoroacetic acid / dichloromethane / 1 h / -78 - 20 °C

With lithium aluminium tetrahydride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;