Technology Process of 4-amino-N-((4-benzyl-2-morpholinyl)-methyl)-5-chloro-2-ethoxybenzamide
There total 9 articles about 4-amino-N-((4-benzyl-2-morpholinyl)-methyl)-5-chloro-2-ethoxybenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) H2, acetic acid / 1.) Raney nickel / 1.) 95 percent EtOH, RT, 2.) CHCl3, RT, 2 h
2: 100 percent / 10percent HCl / 4 h / Heating
3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature
With
hydrogenchloride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
nickel;
In
dichloromethane;
DOI:10.1021/jm00167a020
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3 h / 80 °C
2: concd. H2SO4 / 1 h / 150 °C
3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature
With
sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
DOI:10.1021/jm00167a020
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 83 percent / dimethylformamide / 5 h / Heating
2: 88 percent / 85percent hydrazine monohydrate / ethanol / 0.5 h / Heating
3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature
With
hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a020