1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid

Base Information

Chemical Name:1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid
CAS No.:210917-80-9
Molecular Formula:C₁₉H₂₅FN₄O₅S
Molecular Weight:440.496
Hs Code.:

Synonyms:1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid

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Chemical Property of 1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid

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Technology Process of 1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid

There total 11 articles about 1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 210917-80-9
1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Pd(OAc)2

2: HCl

3: NaOH

4: ClSO₃H

5: PCl₅

With hydrogenchloride; chlorosulfonic acid; palladium diacetate; sodium hydroxide; phosphorus pentachloride;
DOI:10.1016/j.bmcl.2003.08.076

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 210917-80-9
1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: HCl; AcOH

2: HCl

3: NaOH

4: ClSO₃H

5: PCl₅

With hydrogenchloride; chlorosulfonic acid; sodium hydroxide; phosphorus pentachloride; acetic acid;
DOI:10.1016/j.bmcl.2003.08.076

Reference yield:

: 138647-52-6
4-(4-fluorophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 210917-80-9
1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonyl]-4-(N,N-dimethylaminocarbonyl)piperazine-2-(R)-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: HCl

2: NaOH

3: ClSO₃H

4: PCl₅

With hydrogenchloride; chlorosulfonic acid; sodium hydroxide; phosphorus pentachloride;
DOI:10.1016/j.bmcl.2003.08.076