2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

Base Information

Chemical Name:2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride
CAS No.:63429-35-6
Molecular Formula:C₁₉H₂₃N₅OS*2ClH
Molecular Weight:442.412
Hs Code.:

Synonyms:2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

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Chemical Property of 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

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Technology Process of 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

There total 7 articles about 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 63204-31-9
5-(4-methyl-benzyl)-2-methylsulfanyl-3H-pyrimidin-4-one

: 38585-67-0
4-{[(2-aminoethyl)thio]methyl}-5-methylimidazole

: 63429-35-6
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

Guidance literature:: at 140 - 150 ℃; for 5h;
DOI:10.1016/0223-5234(88)90167-5

Reference yield:

: 97585-04-1,20511-20-0,24393-49-5
ethyl (E)-3-(4-methylphenyl)acrylate

: 63429-35-6
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / 5percent Pd/C / ethanol

2: sodium wire / diethyl ether / 18 h / Ambient temperature

3: ethanol / 7 h / Heating

4: 94 percent / aq. NaOH / ethanol / 60 °C

5: 53 percent / 5 h / 140 - 150 °C

With sodium hydroxide; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1016/0223-5234(88)90167-5

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 63429-35-6
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1) piperidine, 2) conc. H₂SO₄ / 1) pyridine

2: hydrogen / 5percent Pd/C / ethanol

3: sodium wire / diethyl ether / 18 h / Ambient temperature

4: ethanol / 7 h / Heating

5: 94 percent / aq. NaOH / ethanol / 60 °C

6: 53 percent / 5 h / 140 - 150 °C

With piperidine; sodium hydroxide; sulfuric acid; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1016/0223-5234(88)90167-5