(3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone

Base Information

• Chemical Name: (3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone
• CAS No.: 77832-49-6
• Molecular Formula: C₁₈H₁₅Cl₂NO₂
• Molecular Weight: 348.229
• Mol file: 77832-49-6.mol

Synonyms:(3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone

Chemical Property of (3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone

There total 2 articles about (3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.4%

2-isopropyl indolizine (58963-30-7) + chlorure de dichloro-3,5 hydroxy-4 benzoyle (59595-92-5) → (3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone (77832-49-6)

Guidance literature:

In 1,2-dichloro-ethane; for 40h; Ambient temperature;

Reference yield:

3,5-dichloro-4-hydroxybenzoic acid (3336-41-2) → (3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone (77832-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / thionyl chloride / dimethylformamide / 2 h / Ambient temperature

2: 25.4 percent / 1,2-dichloro-ethane / 40 h / Ambient temperature

With thionyl chloride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield: 94.9%

1-chloro-3-(dipropylamino)propane (39743-36-7) + (3,5-Dichloro-4-hydroxy-phenyl)-(2-isopropyl-indolizin-3-yl)-methanone (77832-49-6) → [3,5-Dichloro-4-(3-dipropylamino-propoxy)-phenyl]-(2-isopropyl-indolizin-3-yl)-methanone; compound with oxalic acid (79283-21-9)

Guidance literature:

With potassium carbonate; In acetone; for 20h; Heating;

upstream raw materials:

2-isopropyl indolizine

chlorure de dichloro-3,5 hydroxy-4 benzoyle

3,5-dichloro-4-hydroxybenzoic acid

Downstream raw materials:

[3,5-Dichloro-4-(3-dibutylamino-propoxy)-phenyl]-(2-isopropyl-indolizin-3-yl)-methanone; compound with oxalic acid

[3,5-Dichloro-4-(3-dipropylamino-propoxy)-phenyl]-(2-isopropyl-indolizin-3-yl)-methanone; compound with oxalic acid