4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe

Base Information

Chemical Name:4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe
CAS No.:813432-37-0
Molecular Formula:C₄₁H₅₆N₄O₉
Molecular Weight:748.917
Hs Code.:

Synonyms:4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe

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Chemical Property of 4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe

Chemical Property:

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Technology Process of 4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe

There total 7 articles about 4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 126430-46-4
benzyl 4-bromobutanoate

: 813432-35-8
4-(7-hydroxy-quinoline-2-yloxy)butyryl-Val-Leu-Val-OMe

: 813432-37-0
4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 24h;
DOI:10.1021/jm040833q

Reference yield:

: 70500-72-0
7-hydroxy-1H-quinolin-2-one

: 813432-37-0
4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / propan-2-ol / 4 h / Heating

2: 40 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

3: 84 percent / KOH / methanol / 4 h / Heating

4: 93 percent / HBTU; triethylamine / dimethylformamide / 24 h / 20 °C

5: 99 percent / H₂ / Pd/C / methanol / 24 h

6: 65 percent / K₂CO₃ / dimethylformamide / 24 h / 50 °C

With potassium hydroxide; hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm040833q

Reference yield:

: H-Val-Leu-Val-OMe

: 813432-37-0
4-[7-(3-benzyloxycarbonyl-propoxy)quinolin-2-yloxy]butyryl-Val-Leu-Val-OMe

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / HBTU; triethylamine / dimethylformamide / 24 h / 20 °C

2: 99 percent / H₂ / Pd/C / methanol / 24 h

3: 65 percent / K₂CO₃ / dimethylformamide / 24 h / 50 °C

With hydrogen; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm040833q